In recent days, the hottest political story [VIDEO] has revolved around the speculation that Oprah Winfrey could run for president in 2020. In response, Donald Trump made a prediction.

Trump on Oprah

It all started during the 75th anniversary Golden Globe Awards when Oprah Winfrey took to the stage to accept the Cecil B. DeMille Award for her contributions to the world of entertainment. While not mentioning Donald Trump by name, it was clear she was sending a message to the current state of politics and culture in the United States. Oprah addressed the growing awareness of sexual assault and harassment ever since the bombshell New York Times report exposed decades of sexual misconduct at the hands of film producer Harvey Weinstein, which led to many more women coming forward with similar stories.

Oprah then spoke about her struggles as a young African-American woman raised by a hard-working single mother, as she pushed the need to come together and fight against racism an other forms of prejudice. In response, social media went viral [VIDEO]as many pushed for Oprah to run for president. Her longtime partner, Stedman Graham, spoke after the show and indicated that it could be a possibility, saying it was "up to the people." As reported by CBS News on January 9, Donald Trump has decided to make his first public comments about a potential race against his old friend in 2020.

While meeting with lawmakers at the White House to discuss immigration, Donald Trump was asked about an Oprah Winfrey run for president in 2020.

"I'll beat Oprah. Oprah would be a lot of fun," Trump said.

"I know her very well. I did one of her last shows," Donald Trump added. "I like Oprah. I don't think she's going to run," he went on to say. Within minutes of his comments, the president faced backlash on social media.

Twitter reaction

After Donald Trump predicted a win over Oprah Winfrey, critics on Twitter hit back. "WTF does this mean: 'Oprah would be a lot of fun,'"one tweet read.

"You can't even beat yourself. #RussianCollusion," another Twitter user added. "Only way Donald Dump would win is if election votes were changed as they were in 2016.

So yeah..." an additional tweet stated. "Trump will lose in a landslide no matter who he faces, but I’m betting he won’t last long enough to find out," a follow-up tweet noted.

"Donald Trump couldn’t beat Hillary Clinton in the popular vote. Good luck trying to beat Oprah," a tweet read. "I would love to hear what nickname he would give her. It would fly right back in his face. She is the one person in America he can't tag. Let him try," a social media user wrote.