NFL Fantasy Football Rankings: Top 5 RBs for Week 5 matchups

The Arizona running back gets a good matchup here against a 49ers team giving up a good bit of fantasy points to running backs. Johnson needs a breakout game early in the season and this looks like as good a place as any to get one. Keep an eye on the Cardinals to take advantage of a hurting San Francisco team.

Gurley currently ranks second only to Ezekiel Elliott in total yards, with his 338 for the season. However, he's got double the touchdowns that Zeke does this season, so far, and zero fumbles. In Week 5, Gurley is against a Seattle Seahawks team ranked No. 27 in terms of total rushing yards allowed this season.

Kamara heads toward a "Monday Night Football" clash with the Washington Redskins' defense. The main concern with Kamara, will be Mark Ingram starting to get more touches, as well as fewer possible goal-line scoring opportunities. For now, Kamara seems like a safe option as fantasy owners keep a close watch on his situation.

Elliott is a no-brainer for running backs pretty much every week. In last week's game, he put up a stellar total of nearly 250 yards and a touchdown through passing and rushing plays. He'll face a tougher defense in Houston, but is still capable of pushing through for big stats this week.

Gordon has 276 yards and two touchdowns so far this season. The Oakland Raiders' rushing defense ranks No. 30 in the league for total yards allowed. That gives Gordon a good opportunity to add some additional stats for himself, his team, and, of course, fantasy owners.