5 top NCAA football games, odds, trends for Week 5, including Ohio State vs Penn State

This is the biggest game of the week, bar none! The 4-0 Nittany Lions will host the 4-0 Ohio State Buckeyes in a game that could have national championship implications. The No. 9 ranked Nittany Lions are averaging 55.5 points per game, while the No. 4 team in the country is averaging 54. Penn State has been pure gold at the Vegas window over the past three seasons compiling a 20-5-2 record ATS in their last 27 games overall.

For the first time since 2005, Notre Dame will host an opponent while both teams are ranked in the Top 10. The No. 8 Fighting Irish will host No. 7 Stanford in a primetime matchup at 7:30 PM ET from South Bend, Indiana. The Irish haven’t fared well against teams with a winning record of late as they are 2-6 ATS in their last eight games overall.

Starting the 2018 season, BYU was unranked and not thought of by many as capable of making a run at the top 10. Following a 3-1 start, including a huge upset win at Wisconsin, the Cougars are making noise. If they defeat the No. 11 Huskies in Washington, the sky's the limit for BYU. Just like the game in Madison, BYU is more than a two-touchdown underdog for this weekend’s game. The home team has won this matchup seven of the last nine times.

No. 17 Kentucky will host South Carolina this Saturday (September 29) in a game that is unfamiliar territory for the Wildcats. Kentucky will be trying to win their fifth straight game and start the season 5-0 for the first time since 2007. The Wildcats odds of starting 6-0 look good, as they have defeated South Carolina four consecutive times.

While Michigan comes into this game as a 14-point favorite, it is a huge game for the Wolverines. Coach Harbaugh’s team has not fared well on the road in the Big Ten and Northwestern has a reputation of playing very well at home. The underdog in this series is 6-2 ATS over the past eight meetings.