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The #Washington Redskins will play host to the San Francisco 49ers Sunday at FedExField. The Redskins are big favorites [VIDEO], but also have their fair share of injuries as well. The 49ers have yet to win a game this season despite being in contention late in almost every game they've played this year.

San Francisco's rookie head coach is former Redskins offensive coordinator Kyle Shanahan, who would love nothing more than to get his first #NFL victory against his former employer.

Jay Gruden spoke about injuries at his press conference Friday

Washington head coach Jay Gruden addressed the #Redskins Injury Report Friday at his press conference with members of the media.

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“Out will be Josh Norman, rib; Ty Nsekhe, core muscle. Doubtful is Rob Kelley, ankle; Deshazor Everett, hamstring. Questionable will be Trent Williams, knee.”

Not having Ty Nsekhe and Josh Norman [VIDEO] was expected, the thought of not having Trent Williams is scary, he is, without doubt, the best player on the entire Redskins roster. While the injury report officially lists Williams as questionable, Gruden did everything but say the veteran tackle would play saying that when Trent tells him "he can go," then he can go. Gruden said that team doctors would make a final call on Trent Saturday morning, but all signs point to him playing this weekend.

Gruden was further asked about runningback Robert Kelley's availability for Sunday, he responded by saying Kelley had not practiced, and would "be a long shot" to play Sunday.

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Those words mean that rookie back Samaje Perine will likely get the second NFL start of his young career while Kelley rests his ankle for another week. Officially, Kelley will be a game-time decision along with safety Deshazor Everett. If Everett can't go Gruden said earlier in the week that Joshua Holsey would likely get the nod on dressing for the day and that Kendall Fuller would be the emergency third safety for the team in case they needed him in the role.

The rest of the Redskins injury report

While Washington has the five main injuries to players who missed practice on Friday, the team also has five other players currently listed on the report that did participate in Friday's activities. Safeties Montae Nicholson (shoulder) and D.J. Swearinger (hamstring) were both full participants as were linebackers Mason Foster (shoulder) and Zach Brown (sick), as well as receiver Josh Doctson (shoulder), all were listed as full participants in Friday's practice session.

Players who found themselves off of the injury list this week after being there most of this season were receiver Jamison Crowder and tight end Jordan Reed.

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Both look to play considerable roles in the Redskins offense moving forward after being non-factors thus far this season.

Key San Francisco injuries

The San Francisco 49ers will come into the game with five players listed as questionable and one listed as out. Safeties Eric Reed (knee) and Adrian Colbert (hamstring), along with linebackers Dekoda Watson (groin) and Reuben Foster (ankle), as well as cornerback Ahkello Witherspoon (concussion) were all limited in practice Friday and will be game-time decisions. Fullback Kyle Juszczyk (back) was the only player listed as out.

The team released veteran linebacker, Navorro Bowman, this afternoon. The Niners had been trying to trade Bowman over the past few weeks.