The late games of Week 10 in the NFL bring some of the best and worst teams in Football to the forefront, sometimes in the same game. The biggest game of the entire week occurs on Sunday night, when two teams who faced each other in Super Bowl XLIX meet for the first time since that memorable championship. To refresh yourself on the predictions for the early games of the week, click here.

Miami Dolphins at San Diego Chargers, Sunday 4:05 ET

The running games of these two seesawing teams will be in full focus. Melvin Gordon has been one of the best running backs in the NFL after failing to score a touchdown during his rookie season with the Chargers.

Meanwhile, Jay Ajayi has been on such a tear that Arian Foster, who was the starter at the beginning of the season, retired. Chargers 22, Dolphins 20

Dallas Cowboys at Pittsburgh Steelers, Sunday 4:25 ET

Ben Roethlisberger didn't look terribly healthy in his return from an injury in last week's loss to Baltimore, which has thrown the Steelers' season into question. The Cowboys have the best record in the NFC, but with Tony Romo just about ready to come back, this team is about to face some major turbulence -- it starts this week. Steelers 27, Cowboys 19

San Francisco 49ers at Arizona Cardinals, Sunday 4:25 ET

They may have a win in the bag, but San Francisco is probably the worst team in the NFL.

The Cardinals should be able to run and pass all over the weak defense and turn this into the biggest blowout of the week. Cardinals 37, 49ers 6

Seattle Seahawks at New England Patriots, Sunday 8:30 ET

Back in Super Bowl XLIX, the Seahawks became mocked after choosing to try to pass the ball at the goal line at the end of the game, resulting in a season-ending interception by Malcolm Butler.

Butler is still ready to harass the Seattle passing game, but the Seahawks just don't have the same offensive spark as NFL fans have grown accustomed to -- also, they're on the road. Patriots 24, Seahawks 14

Cincinnati Bengals at New York Giants, Monday 8:30 ET

The Giants are an extremely streaky team, and since they've been trending in the right direction for some time, they're due for a let-up in this game.

The Bengals are fighting for their season on Monday night, and they'll get it done on the road. Bengals 21, Giants 17

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