As always is unfortunately the case, injuries frequently occur in the NFL.
There is already a large group of players who are already set to miss a substantial amount of time in the regular season, if not the whole year.
Here is a notable group of players who will be sidelined a while. Players such as quarterback Alex Smith who were injured last season are not included.
A whole list of player injuries can be found on ESPN.
Robert Alford (CB) - Cardinals
There is no timetable for his return, but Alford is expected to miss a considerable amount of time with a fractured tibia. Previously, he started 72 games over the past five seasons for the Falcons recording eight interceptions over that time.
Isaiah Crowell (RB) - Raiders
Crowell tore his Achilles in a late February team practice, an injury that will likely keep him out all season. He has rushed for 3,803 yards over five seasons with the Browns and Jets in his career.