Stan Wawrinka has withdrawn from the Rogers Cup due to a knee injury. It’s the first time since 2012 that he’ll miss the prestigious Tennis tournament.

Wawrinka a three-time Grand Slam champion (2014 Australian Open, 2015 French Open, and 2016 US Open) was seeded fourth at the Masters 1000 tournament. There’s no word yet on if the injury will prevent him from playing in the upcoming U.S. Open.

Rogers Cup Tournament Director Eugene Lapierre spoke about Wawrinka having to miss the event. Lapierre noted how loyal Wawrinka has been to the tournament and that it's a disappointment he won't be able to play this year.

Lapierre also wished Wawrinka to have a quick recovery.

Raonic moves up

With Wawrinka dropping out, Milos Raonic moves up from the ninth seed to number eight. It’s a significant move for the Canadian as the top eight seeds earn first-round byes. Raonic figures to be a fan favorite with the event in Montreal.

John Isner now moves into the list of seeded players at number 16. The American comes into the Rogers Cup hot with two consecutive tournament victories (Newport and Atlanta).

The top ranked player in the world, Andy Murray, enters the Rogers Cup as the top seed. He’s followed by Rafael Nadal, Roger Federer, and Marin Cilic. The rest of the top 10 seeds are Dominic Theim, Alexander Zverev, Kei Nishikori, Raonic, Grigor Dimitrov and Jo-Wilfred Tsonga.

Also seeded are David Goffin, Tomas Berdych, Pablo Carreno Busta, Roberto Bautista Agut, Lucas Pouille, and Isner.

Pliskova takes top seed

On the women’s side of the draw, new world number one Karolina Pliskova is the top seed. She’s followed by Simona Halep, Angelique Kerber and 2017 Wimbledon champion Garbine Muguruza. The rest of the top 10 seeds are Elina Svitolina, Caroline Wozniacki, Johanna Konta, Svetlana Kuznetsova, Venus Williams and Agnieszka Radwanska.

Williams is the only seeded American in the women's field. Her sister, Serena, remains out of tour action as she prepares to have a baby.

Multiple locations in Canada

The men will compete this year's Rogers Cup in Montreal, while the women will battle it out in Toronto. Halep is the defending champion on the women's side, while Novak Djokovic is the reigning champ on the men's side.

Djokovic is out of action as he tries to recover from an elbow issue.

The Rogers Cup is presented by National Bank and the tournament is administered by Tennis Canada. First-round action in both venues begins on Monday. The finals are slated for Sunday, Aug. 13.