The second leg of the UEFA Champions League kicks off with Napoli trying to come back from a 3-1 hole it suffered at Real Madrid a few weeks ago. Napoli is only 2-2 since the first leg in all competition, but was able to upset Roma 2-1 over the weekend in Serie A.

Real Madrid's recent form in La Liga has been 3-1-1 and are one point behind Barcelona for the top spot. Kickoff is set for Tuesday at 2:45 PM Eastern time in San Paolo, Naples, and the match can be seen on Fox Sports 2 and online with Fox Sports Go and Fubo TV.

Real Madrid (18-6-2 in La Liga)

Toni Kroos was the difference maker in the first leg, getting the team's second goal four minutes into the second half and breaking the 1-1 tie. Casemiro knocked in a third goal five minutes later and the team held Napoli scoreless after the opponent kicked an opening goal eight minutes into the contest.

Zinedine Zidane's side should be well rested as players like Kroos and Cristiano Ronaldo were out in their latest game in league play. It's been a busy time for them as they've needed to make up some games in La Liga due to prior postponements.

Napoli (17-6-4 in Serie A)

While the home side will be tasked with a big challenge of mounting a comeback over one of Spain's best clubs, their recent win over Roma should give them a lot of confidence.

Lorenzo Insigne was the man responsible for the first goal of the first leg, his first score in Champions League play this season in nine shot attempts. With that away goal, Napoli only needs to score two goals while maintaining a clean sheet to advance.

With both defenses being vulnerable heading into this game, expect Napoli to come out firing like it did in the first match.

Their main issue will be how to contain Real Madrid. The spotlight can't just be on Ronaldo -- he's gotten his team involved in Champions League play with five assists and two goals in his seven appearances.

Odds in this leg are set with Napoli as 17/10 to win, Real Madrid as 13/10 to win, and a draw is 14/5. With a two-goal lead under their belt, Real Madrid is the favorite to move on to the Champions League quarterfinals.