On Saturday, the NCAA College Football Week 12 point spreads and odds feature several huge favorites. Among them are the LSU Tigers, Ohio State, and the USC Trojans. The Oklahoma Sooners are also favorites, but by not as many points, as they'll face a ranked squad in a primetime matchup. Alabama, the No. 1 team in the nation, is also expected to dominate in their Week 12 matchup. Here's a look at the latest betting lines ahead of Saturday's college football action in Week 12.

LSU is a 14-point favorite over Florida

The two teams finally get their game on with a meeting that originally was going to take place on October 8th.

Instead, the game was rescheduled due to the fierce Hurricane Matthew. Now Leonard Fournette appears healthy and will be on the field as the LSU vs. Florida live game goes down at 1 p.m. Eastern Time.

The home team Tigers are a favorite by two touchdowns. The Gators are without three of their defensive players, which could allow Fournette a big day at home. There's also his teammate Derrius Guice who hasn't done so bad on the ground either. He currently leads the team with 881 yards total rushing and has nine touchdowns. Watch out for these backs as they try to run all over the Gators.

Ohio State is an even bigger favorite

The Buckeyes continue their attempts to secure a College Football Playoffs position.

With just one loss happening, and it coming in their Big Ten division, they can't afford to lose to a team with a losing record. Michigan State will stil try to give them a tough battle as they'll host the game at 12 p.m. Eastern Time.

OSU is listed as a whopping 22-point favorite. That means they'll need to put a lot of points on the board.

Based on their previous two results, both of which were 62-3 routs they seem to have no trouble doing just that. Watch out for a huge score in this battle as the OSU vs. MSU live game takes place early Saturday for the college football slate.

Who else is expected to win?

The No. 1 Alabama Crimson Tide play at 7 p.m.

ET. They'll host Chattanooga in what is expected to be a rout at Bryant-Denny Stadium. The Crimson Tide largely considered this year's championship team, are off the board for the betting lines as of this report. However, based on a 2013 result where they defeated Chattanooga by 49-0, bettors can figure a large disparity is there again.

The 9-1 Clemson Tigers will take on Wake Forrest in North Carolina starting at 7 p.m. ET. Clemson, the No. 4 team in the rankings, will be a huge favorite by 24 points here as they look to stay among potential playoff teams.

At 8 p.m. Eastern Time, the Oklahoma Sooners battle the West Virginia Mountaineers in the Big 12. OU is considered the favorite, but by a slim four points, as they try to keep their high ranking.

The USC Trojans are the No. 13 team in the Top 25 and will visit UCLA at 10:30 p.m Eastern Time. Right now, USC is expected to win by two touchdowns in this late night college football showdown.

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