Fantasy Football is full of challenges and intriguing decisions. The draft isn't the only time when an owner is forced to make tough choices. The choices come weekly, when owners have to pick the best running backs, receivers, and quarterbacks every week. And sometimes an owner has an opportunity to take advantage of a certain matchup with sleeper players who wouldn't ordinarily be solid plays. Here are five of those players who could go off in week 1.

1. Jared Cook

First of all, this is a huge risk.

Cook will likely split time with fellow tight end Richard Rodgers, reducing his chances for more fantasy points. But the matchup makes this risky play worth it. The Jaguars ranked struggled to defend the tight end last season, allowing the 6th most fantasy points to opposing tight ends. Aaron Rodgers hasn't had a tight end with the talent of Cook in a while and will take advantage of the unique opportunity against a weak Jaguars defense.

2. Charles Sims

The Buccaneers backup running back can be considered a legitimate fantasy option this week against a Falcons team that struggles to defend the run.

Sims wasn't bad as a backup last season either, ranking within the top 25 in fantasy points scored for running backs. Don't be surprised if Sims manages to put up some decent fantasy numbers in his game against the Falcons.

3. Isaiah Crowell

The Cleveland Browns starter didn't have an awful season last year, finishing with 888 rushing yards and five touchdowns. He draws a favorable matchup in week 1 against an Eagles defense that struggles to defend the run. Duke Johnson will take his receiving touches, but Crowell should still be considered a legitimate fantasystarter in week 1.

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4. Derek Carr

The Saints Raiders game will probably be the highest scoring of the entire week. Both teams have potent offenses to go with lackluster defenses, a recipe for massive fantasy success. Carr has another year of experience and is continuing to improve with the addition of Amari Cooper. Carr should definitely be played instead of a number of other quarterbacks, including Cam Newton.

5. Michael Crabtree

I'm sticking to the Raiders Saints game with my next pick. Carr will need to throw to more than one receiver to have a huge game and Crabtree is the perfect guy.

Crabtree actually ranked within the top 20 fantasy receivers thanks to a season that included more than 900 receiving yards and 9 touchdowns. Crabtree is an excellent sleeper play in week 1 and he will probably reach double digit fantasy points against a poor Saints defense.

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