Most people have heard about the suicides of two Celebrities last week. It was shocking, but if anything good can come out of the tragedies, there are lots of conversations about depression that might prevent others from taking their own lives.

Designer Kate Spade [VIDEO], 55, and host of the CNN travel show "Parts Unknown" Anthony Bourdain [VIDEO], 61, did not kill themselves because of money problems as some people do. They were successful and financially stable.

After Spade's death, information came out that she was seeking help for depression and anxiety. She was seeing medical professionals regularly. She was also taking medication for her condition.

Here are at least five major symptoms to pay attention to if you are depressed or if you know someone who might be depressed. These warning signs are helpful because the World Health Organization reports that more than 300 million people suffer from depression.

1. Changes in sleep pattern

If you have never had a problem sleeping before, obvious changes in your sleep pattern might be a symptom that you are depressed. If you are finding yourself sleeping less or sleeping more, it could be an indication of depression, according to Dr. Joseph Calabrese, a professor of psychiatry and director of the Mood Disorders Program at University Hospitals Cleveland Medical Center.

2. Confused mind

You might be depressed if you used to stay focused most of the time, but now you are confused and can't think clearly. Depressed people speak slower because it takes longer for them to get their thoughts together. They might forget important things and have a hard time making intelligent decisions.

3. Excessive worry

Excessive worry might be a sign of depression. If you find yourself worrying about things that didn't concern you in the past, then it could be a warning.

4. Change in weight

When people are depressed, they might not eat as much as they used to because they lose interest in food. Some people will eat more than usual because stress will cause them to eat everything in sight. Eating less or eating more will cause people's weight to change.

That might be a sign of depression because of chemical changes in the brain.

5. Isolation

Isolation is a big sign of depression, especially if people who used to be social butterflies have become withdrawn. They give excuses to stay home instead of going out with family and friends. They might say they are not feeling well. That could be true because depressed people often suffer from headaches or other ailments.

If you are depressed or someone you know shows signs of depression that could lead to suicide, call the U.S. National Suicide Prevention Lifeline at 1-800-273-8255.