Go big or go home! That may be an underlying theme for the second Spider-Man film under the MCU's guidance. Tom Holland reprises his role for the movie set to take place just after the story in "Avengers 4" ends. It could mean the popular web-slinger has to fight a number of villains this time around. Jake Gyllenhaal is rumored to take on the role of classic villain Mysterio and Michael Keaton will return as The Vulture. Good luck Spidey!