Over the last few months, Texas Sen. Ted Cruz was considered the only legitimate threat to Republican front runner Donald Trump. After finishing in last place at the New York primary two weeks ago, in addition to five primary loses this past Tuesday, the senator from the Lone Star State decided to announce who his running mate would be if he makes it to the general election in November.

Maher on Cruz

After a surge to start 2016, Cruz has hit a wall over the last month and it appears his chances to become the nominee are over. Never one to shy away from his political views, liberal comedian and talk show host, Bill Maher, let loose on Cruz, and the rest of the conservatives running for president, during the April 29 edition of "Real Time with Bill Maher" on HBO.

Maher opened his show with his usual monologue, pointing out Cruz's bad month, from his failed attempt at a partnership with Ohio Gov. John Kaisch, to his string of loses in the primaries. "(Cruz) started an alliance with John Kasich. It's just like a reality show—they're making alliances," Maher said, before stating, "He placed last in four out of the five primaries on Tuesday, he picked a running mate, for a race he will not be running." Continuing, Maher poked fun at Cruz for picking former CEO of Hewlett Packard and failed presidential candidate, Carly Fiorina.

"They had a big ceremony and Carly came out," Maher said, noting, "It was like Hitler marrying Eva Braun in the bunker, except sad."

Maher didn't refrain from criticism of Trump, either, as he went hard on his recent attacks on Hillary Clinton.

The billionaire real estate mogul recently accused Clinton of "playing the woman card," to which Maher used to his comedic advantage. "Uh, no Don, women don"t like you. They don’t like you big-time,” Maher said, stating, "Have you seen his numbers with women? He's like menstrual cramps in a suit." In his biggest shot on Trump, Maher referred to him as a "f**king b*tch."

State of the race

After Tuesday's "Super Tuesday" primary contests, Trump and Clinton walked out the big winners.

All signs point to a Trump-Clinton general election match-up despite pushback from many on the left and right. According to Real Clear Politics most recent rolling average, Clinton holds a commanding lead on Trump in a hypothetical general election race, 49 percent to 40.5 percent.